ABSTRACT
In the present study, Uvaria narum (Annonaceae) leaves were evaluated for its possible hepatoprotective potential. Elevation in hepatic biomarkers like SGPT, SGOT, ALP, bilirubin & other biochemical parameters like Cholesterol, triglycerides, urea & tissue LPO, where as decrease in total protein, albumin, glucose & tissue GSH, CAT, SOD was observed in CCl4 induced liver toxicity. Treatment with Silymarin, UNLE-200 and UNLE -400 resorted the altered hepatic biomarkers and biochemical parameters significantly in dose dependent manner. The biochemical observations were supplemented by histopathological examinations of liver sections. Relative organ weights were also reduced dose dependently in extract treated rats. Overall observations indicates that UNLE exerted remarkable hepatoprotective efficacy against CCl4 induced liver damage were comparable to reference standard Silymarin (100mg/kg) that is, may be due to its augmenting endogenous antioxidant mechanisms. These findings suggest the use of plant for treatment of liver diseases in oriental traditional medicine.
ABSTRACT
The present work has been designed to evaluate the potency of anti-inflammatory activity of different fractions of ethanolic extract of Achyranthes aspera leaves. Carrageenan induced rat paw oedema method was used for screening. Ethanolic, ethyl acetate and hexane fraction was screened among which ethyl acetate fraction was found to be most potent one with percentage inhibition of 50, 74, 84, 86% at 1st to 4th hour respectively. By this experiment it seems that leaves of Achyranthes aspera can be used for the treatment of acute inflammation.